Pgc-1α Overexpression Downregulates Pitx3 and Increases Susceptibility to MPTP Toxicity Associated with Decreased Bdnf

Multiple mechanisms likely contribute to neuronal death in Parkinson’s disease (PD), including mitochondrial dysfunction and oxidative stress. Peroxisome proliferator-activated receptor gamma co-activator-1 alpha (PGC-1α) positively regulates the expression of genes required for mitochondrial biogen...

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Detalles Bibliográficos
Autores principales: Clark, Joanne, Silvaggi, Jessica M., Kiselak, Tomas, Zheng, Kangni, Clore, Elizabeth L., Dai, Ying, Bass, Caroline E., Simon, David K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3492133/
https://www.ncbi.nlm.nih.gov/pubmed/23145024
http://dx.doi.org/10.1371/journal.pone.0048925

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3492133/
https://www.ncbi.nlm.nih.gov/pubmed/23145024
http://dx.doi.org/10.1371/journal.pone.0048925

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