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Protein Tyrosine Phosphatase Receptor Type Z Negatively Regulates Oligodendrocyte Differentiation and Myelination

BACKGROUND: Fyn tyrosine kinase-mediated down-regulation of Rho activity through activation of p190RhoGAP is crucial for oligodendrocyte differentiation and myelination. Therefore, the loss of function of its counterpart protein tyrosine phosphatase (PTP) may enhance myelination during development a...

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Detalles Bibliográficos
Autores principales: Kuboyama, Kazuya, Fujikawa, Akihiro, Masumura, Makoto, Suzuki, Ryoko, Matsumoto, Masahito, Noda, Masaharu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3492236/
https://www.ncbi.nlm.nih.gov/pubmed/23144976
http://dx.doi.org/10.1371/journal.pone.0048797