Hyperactivation of PARP Triggers Nonhomologous End-Joining in Repair-Deficient Mouse Fibroblasts

Regulation of poly(ADP-ribose) (PAR) synthesis and turnover is critical to determining cell fate after genotoxic stress. Hyperactivation of PAR synthesis by poly(ADP-ribose) polymerase-1 (PARP-1) occurs when cells deficient in DNA repair are exposed to genotoxic agents; however, the function of this...

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Detalles Bibliográficos
Autores principales: Gassman, Natalie R., Stefanick, Donna F., Kedar, Padmini S., Horton, Julie K., Wilson, Samuel H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3492265/
https://www.ncbi.nlm.nih.gov/pubmed/23145148
http://dx.doi.org/10.1371/journal.pone.0049301

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3492265/
https://www.ncbi.nlm.nih.gov/pubmed/23145148
http://dx.doi.org/10.1371/journal.pone.0049301

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