Identification of Sumoylation Sites in CCDC6, the First Identified RET Partner Gene in Papillary Thyroid Carcinoma, Uncovers a Mode of Regulating CCDC6 Function on CREB1 Transcriptional Activity

CCDC6 was originally identified in chimeric genes as caused by chromosomal translocation involving the RET protooncogene in some thyroid tumors. Recognised as a 65 kDa pro-apoptotic phosphoprotein, CCDC6 has been enrolled as an ATM substrate that contribute to protect genome integrity by modulating...

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Detalles Bibliográficos
Autores principales: Luise, Chiara, Merolla, Francesco, Leone, Vincenza, Paladino, Simona, Sarnataro, Daniela, Fusco, Alfredo, Celetti, Angela
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3492267/
https://www.ncbi.nlm.nih.gov/pubmed/23145146
http://dx.doi.org/10.1371/journal.pone.0049298

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3492267/
https://www.ncbi.nlm.nih.gov/pubmed/23145146
http://dx.doi.org/10.1371/journal.pone.0049298

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