Cargando…

Targeting COX-2/PGE(2) Pathway in HIPK2 Knockdown Cancer Cells: Impact on Dendritic Cell Maturation

BACKGROUND: Homeodomain-interacting protein kinase 2 (HIPK2) is a multifunctional protein that exploits its kinase activity to modulate key molecular pathways in cancer to restrain tumor growth and induce response to therapies. For instance, HIPK2 knockdown induces upregulation of oncogenic hypoxia-...

Descripción completa

Detalles Bibliográficos
Autores principales:	Garufi, Alessia, Pistritto, Giuseppa, Ceci, Claudia, Di Renzo, Livia, Santarelli, Roberta, Faggioni, Alberto, Cirone, Mara, D’Orazi, Gabriella
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3492329/ https://www.ncbi.nlm.nih.gov/pubmed/23144866 http://dx.doi.org/10.1371/journal.pone.0048342

Ejemplares similares

The Sweet Side of HIPK2
por: Garufi, Alessia, et al.
Publicado: (2023)

HIPK2 in Angiogenesis: A Promising Biomarker in Cancer Progression and in Angiogenic Diseases
por: Garufi, Alessia, et al.
Publicado: (2023)

Hyperglycemia triggers HIPK2 protein degradation
por: Baldari, Silvia, et al.
Publicado: (2016)

HIPK2 as a Novel Regulator of Fibrosis
por: Garufi, Alessia, et al.
Publicado: (2023)

The Impact of NRF2 Inhibition on Drug-Induced Colon Cancer Cell Death and p53 Activity: A Pilot Study
por: Garufi, Alessia, et al.
Publicado: (2022)

HIPK2 role in the tumor–host interaction: Impact on fibroblasts transdifferentiation CAF‐like
por: Garufi, Alessia, et al.
Publicado: (2019)

Reactivation of mutant p53 by capsaicin, the major constituent of peppers
por: Garufi, Alessia, et al.
Publicado: (2016)

p53-Dependent PUMA to DRAM antagonistic interplay as a key molecular switch in cell-fate decision in normal/high glucose conditions
por: Garufi, Alessia, et al.
Publicado: (2017)

p62/SQSTM1/Keap1/NRF2 Axis Reduces Cancer Cells Death-Sensitivity in Response to Zn(II)–Curcumin Complex
por: Garufi, Alessia, et al.
Publicado: (2021)

Zinc supplementation is required for the cytotoxic and immunogenic effects of chemotherapy in chemoresistant p53-functionally deficient cells
por: Cirone, Mara, et al.
Publicado: (2013)

Reduced chemotherapeutic sensitivity in high glucose condition: implication of antioxidant response
por: Garufi, Alessia, et al.
Publicado: (2019)

Apoptosis as anticancer mechanism: function and dysfunction of its modulators and targeted therapeutic strategies
por: Pistritto, Giuseppa, et al.
Publicado: (2016)

A ruthenium(II)-curcumin compound modulates NRF2 expression balancing the cancer cell death/survival outcome according to p53 status
por: Garufi, Alessia, et al.
Publicado: (2020)

JNK and Macroautophagy Activation by Bortezomib Has a Pro-Survival Effect in Primary Effusion Lymphoma Cells
por: Granato, Marisa, et al.
Publicado: (2013)

NRF2 and Bip Interconnection Mediates Resistance to the Organometallic Ruthenium-Cymene Bisdemethoxycurcumin Complex Cytotoxicity in Colon Cancer Cells
por: Garufi, Alessia, et al.
Publicado: (2023)

ZnCl(2) sustains the adriamycin-induced cell death inhibited by high glucose
por: Garufi, A, et al.
Publicado: (2016)

Updates on HIPK2: a resourceful oncosuppressor for clearing cancer
por: D’Orazi, Gabriella, et al.
Publicado: (2012)

Apigenin, by activating p53 and inhibiting STAT3, modulates the balance between pro-apoptotic and pro-survival pathways to induce PEL cell death
por: Granato, Marisa, et al.
Publicado: (2017)

Kaposi sarcoma associated herpesvirus (KSHV) induces AKT hyperphosphorylation, bortezomib-resistance and GLUT-1 plasma membrane exposure in THP-1 monocytic cell line
por: Gonnella, Roberta, et al.
Publicado: (2013)

Autophagy manipulation as a strategy for efficient anticancer therapies: possible consequences
por: Cirone, Mara, et al.
Publicado: (2019)

Activation of dendritic cells by tumor cell death
por: Cirone, Mara, et al.
Publicado: (2012)

NRF2 in Cancer: Cross-Talk with Oncogenic Pathways and Involvement in Gammaherpesvirus-Driven Carcinogenesis
por: Cirone, Mara, et al.
Publicado: (2022)

HIF-1α antagonizes p53-mediated apoptosis by triggering HIPK2 degradation
por: Nardinocchi, Lavinia, et al.
Publicado: (2011)

Unfolded p53 in the pathogenesis of Alzheimer's disease: is HIPK2 the link?
por: Stanga, Serena, et al.
Publicado: (2010)

Primary Effusion Lymphoma Cell Death Induced by Bortezomib and AG 490 Activates Dendritic Cells through CD91
por: Cirone, Mara, et al.
Publicado: (2012)

Cytotoxic Drugs Activate KSHV Lytic Cycle in Latently Infected PEL Cells by Inducing a Moderate ROS Increase Controlled by HSF1, NRF2 and p62/SQSTM1
por: Granato, Marisa, et al.
Publicado: (2018)

HSP70 inhibition by 2-phenylethynesulfonamide induces lysosomal cathepsin D release and immunogenic cell death in primary effusion lymphoma
por: Granato, M, et al.
Publicado: (2013)

HSP70 inhibition by 2-phenylethynesulfonamide induces lysosomal cathepsin D release and immunogenic cell death in primary effusion lymphoma
por: Granato, M, et al.
Publicado: (2014)

HIPK2 modulates p53 activity towards pro-apoptotic transcription
por: Puca, Rosa, et al.
Publicado: (2009)

Glucose restriction induces cell death in parental but not in homeodomain-interacting protein kinase 2-depleted RKO colon cancer cells: molecular mechanisms and implications for tumor therapy
por: Garufi, A, et al.
Publicado: (2013)

Interconnected Adaptive Responses: A Way Out for Cancer Cells to Avoid Cellular Demise
por: D’Orazi, Gabriella, et al.
Publicado: (2022)

KSHV infection skews macrophage polarisation towards M2-like/TAM and activates Ire1 α-XBP1 axis up-regulating pro-tumorigenic cytokine release and PD-L1 expression
por: Gilardini Montani, Maria Saveria, et al.
Publicado: (2020)

Quercetin Interrupts the Positive Feedback Loop Between STAT3 and IL-6, Promotes Autophagy, and Reduces ROS, Preventing EBV-Driven B Cell Immortalization
por: Granato, Marisa, et al.
Publicado: (2019)

Lovastatin reduces PEL cell survival by phosphorylating ERK1/2 that blocks the autophagic flux and engages a cross‐talk with p53 to activate p21
por: Santarelli, Roberta, et al.
Publicado: (2021)

COX-2-PGE(2)-EPs in gynecological cancers
por: Ye, Yao, et al.
Publicado: (2020)

Mutant p53 and Cellular Stress Pathways: A Criminal Alliance That Promotes Cancer Progression
por: D’Orazi, Gabriella, et al.
Publicado: (2019)

The Impact of COVID-19 Infection in Cancer 2020–2021
por: D’Orazi, Gabriella, et al.
Publicado: (2022)

NRF2 and STAT3: friends or foes in carcinogenesis?
por: Arena, Andrea, et al.
Publicado: (2023)

Degradation of mutant p53H175 protein by Zn(II) through autophagy
por: Garufi, A, et al.
Publicado: (2014)

PBA Preferentially Impairs Cell Survival of Glioblastomas Carrying mutp53 by Reducing Its Expression Level, Stabilizing wtp53, Downregulating the Mevalonate Kinase and Dysregulating UPR
por: Romeo, Maria Anele, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_adlohu41dqdpoadqkktl6q9g1v