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c-Fms Signaling Mediates Neurofibromatosis Type-1 Osteoclast Gain-In-Functions

Skeletal abnormalities including osteoporosis and osteopenia occur frequently in both pediatric and adult neurofibromatosis type 1 (NF1) patients. NF1 (Nf1) haploinsufficient osteoclasts and osteoclast progenitors derived from both NF1 patients and Nf1(+/−) mice exhibit increased differentiation, mi...

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Detalles Bibliográficos
Autores principales: He, Yongzheng, Rhodes, Steven D., Chen, Shi, Wu, Xiaohua, Yuan, Jin, Yang, Xianlin, Jiang, Li, Li, Xianqi, Takahashi, Naoyuki, Xu, Mingjiang, Mohammad, Khalid S., Guise, Theresa A., Yang, Feng-Chun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3492362/
https://www.ncbi.nlm.nih.gov/pubmed/23144792
http://dx.doi.org/10.1371/journal.pone.0046900