Cargando…

Identification of ATP-Binding Regions in the RyR1 Ca(2+) Release Channel

ATP is an important modulator of gating in type 1 ryanodine receptor (RyR1), also known as a Ca(2+) release channel in skeletal muscle cells. The activating effect of ATP on this channel is achieved by directly binding to one or more sites on the RyR1 protein. However, the number and location of the...

Descripción completa

Detalles Bibliográficos
Autores principales:	Popova, Olga B., Baker, Mariah R., Tran, Tina P., Le, Tri, Serysheva, Irina I.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3492408/ https://www.ncbi.nlm.nih.gov/pubmed/23144945 http://dx.doi.org/10.1371/journal.pone.0048725

Ejemplares similares

RyR1-related myopathy mutations in ATP and calcium binding sites impair channel regulation
por: Yuan, Qi, et al.
Publicado: (2021)

RyR2 and Calcium Release in Heart Failure
por: Benitah, Jean-Pierre, et al.
Publicado: (2021)

Both RyRs and TPCs are required for NAADP-induced intracellular Ca(2+) release
por: Gerasimenko, Julia V., et al.
Publicado: (2015)

Simvastatin activates single skeletal RyR1 channels but exerts more complex regulation of the cardiac RyR2 isoform
por: Venturi, Elisa, et al.
Publicado: (2018)

Structural and functional interactions between the Ca(2+)-, ATP-, and caffeine-binding sites of skeletal muscle ryanodine receptor (RyR1)
por: Chirasani, Venkat R., et al.
Publicado: (2021)

Structural insights into Ca(2+)-activated long-range allosteric channel gating of RyR1
por: Wei, Risheng, et al.
Publicado: (2016)

Promiscuous attraction of ligands within the ATP binding site of RyR2 promotes diverse gating behaviour
por: Lindsay, Chris, et al.
Publicado: (2018)

How does flecainide impact RyR2 channel function?
por: Salvage, Samantha C., et al.
Publicado: (2022)

Ca(2+)-dependent calmodulin binding to cardiac ryanodine receptor (RyR2) calmodulin-binding domains
por: Brohus, Malene, et al.
Publicado: (2019)

Critical Role of Intracellular RyR1 Calcium Release Channels in Skeletal Muscle Function and Disease
por: Hernández-Ochoa, Erick O., et al.
Publicado: (2016)

Examination of the Effects of Heterogeneous Organization of RyR Clusters, Myofibrils and Mitochondria on Ca(2+) Release Patterns in Cardiomyocytes
por: Rajagopal, Vijay, et al.
Publicado: (2015)

Exercise Training Stabilizes RyR2-Dependent Ca(2+) Release in Post-infarction Heart Failure
por: Danielsen, Tore Kristian, et al.
Publicado: (2021)

Expression of voltage-gated Ca(2+) channels, Insp(3)Rs, and RyRs in the immature mouse ovary
por: Bahena-Alvarez, Daniel, et al.
Publicado: (2022)

Structure of RyR1 in native membranes
por: Chen, Wenbo, et al.
Publicado: (2020)

Identification of RyR2-PBmice and the effects of transposon insertional mutagenesis of the RyR2 gene on cardiac function in mice
por: Wang, Qianqian, et al.
Publicado: (2019)

Dysregulation of RyR Calcium Channel Causes the Onset of Mitochondrial Retrograde Signaling
por: Roy Chowdhury, Anindya, et al.
Publicado: (2020)

Synergistic FRET assays for drug discovery targeting RyR2 channels
por: Rebbeck, RobynT., et al.
Publicado: (2022)

ER stress increases expression of intracellular calcium channel RyR1 to modify Ca(2+) homeostasis in pancreatic beta cells
por: Zhang, Irina X., et al.
Publicado: (2023)

Measurement of RyR permeability reveals a role of calsequestrin in termination of SR Ca(2+) release in skeletal muscle
por: Sztretye, Monika, et al.
Publicado: (2011)

Ca(2+)-Dependent Phosphorylation of RyR2 Can Uncouple Channel Gating from Direct Cytosolic Ca(2+) Regulation
por: Carter, Simon, et al.
Publicado: (2011)

Bidirectional TRP/L Type Ca(2+) Channel/RyR/BK(Ca) Molecular and Functional Signaloplex in Vascular Smooth Muscles
por: Dryn, Dariia O., et al.
Publicado: (2023)

Luminal Ca(2+)–regulated Mg(2+) Inhibition of Skeletal RyRs Reconstituted as Isolated Channels or Coupled Clusters
por: Laver, Derek R., et al.
Publicado: (2004)

Roles of IP(3)R and RyR Ca(2+) Channels in Endoplasmic Reticulum Stress and β-Cell Death
por: Luciani, Dan S., et al.
Publicado: (2009)

Long-term potentiation and spatial memory training stimulate the hippocampal expression of RyR2 calcium release channels
por: Valdés-Undurraga, Ismael, et al.
Publicado: (2023)

On the Adjacency Matrix of RyR2 Cluster Structures
por: Walker, Mark A., et al.
Publicado: (2015)

Review of RyR1 pathway and associated pathomechanisms
por: Witherspoon, Jessica W., et al.
Publicado: (2016)

Snapin, Positive Regulator of Stimulation- Induced Ca(2+) Release through RyR, Is Necessary for HIV-1 Replication in T Cells
por: Kinoshita, Shigemi M., et al.
Publicado: (2013)

Calcium Activation of Ryanodine Receptor Channels—Reconciling RyR Gating Models with Tetrameric Channel Structure
por: Zahradník, Ivan, et al.
Publicado: (2005)

Mitsugumin 53 regulates extracellular Ca(2+) entry and intracellular Ca(2+) release via Orai1 and RyR1 in skeletal muscle
por: Ahn, Mi Kyoung, et al.
Publicado: (2016)

The Central domain of RyR1 is the transducer for long-range allosteric gating of channel opening
por: Bai, Xiao-Chen, et al.
Publicado: (2016)

RyR2 Modulates a Ca(2+)-Activated K(+) Current in Mouse Cardiac Myocytes
por: Mu, Yong-hui, et al.
Publicado: (2014)

Age attenuates the T‐type Ca(V)3.2‐RyR axis in vascular smooth muscle
por: Fan, Gang, et al.
Publicado: (2020)

Acute RyR1 Ca(2+) leak enhances NADH-linked mitochondrial respiratory capacity
por: Zanou, Nadège, et al.
Publicado: (2021)

Loss of S100A1 expression leads to Ca(2+) release potentiation in mutant mice with disrupted CaM and S100A1 binding to CaMBD2 of RyR1
por: Hernández‐Ochoa, Erick O., et al.
Publicado: (2018)

Regulation of ryanodine receptor RyR2 by protein-protein interactions: prediction of a PKA binding site on the N-terminal domain of RyR2 and its relation to disease causing mutations
por: Walpoth, Belinda Nazan, et al.
Publicado: (2015)

Calmodulin Binding to the 3614–3643 Region of RyR1 Is Not Essential for Excitation–Contraction Coupling in Skeletal Myotubes
por: O'Connell, Kristen M.S., et al.
Publicado: (2002)

Functional Characterization of a Central Core Disease RyR1 Mutation (p.Y4864H) Associated with Quantitative Defect in RyR1 Protein
por: Cacheux, Marine, et al.
Publicado: (2015)

RyR2-Mediated Ca(2+) Release and Mitochondrial ROS Generation Partake in the Synaptic Dysfunction Caused by Amyloid β Peptide Oligomers
por: SanMartín, Carol D., et al.
Publicado: (2017)

Contextual Fear Memory Formation and Destabilization Induce Hippocampal RyR2 Calcium Channel Upregulation
por: More, Jamileth, et al.
Publicado: (2018)

1-O-Sulfatobastadins-1 and -2 from Ianthella basta (Pallas). Antagonists of the RyR1-FKBP12 Ca(2+) Channel
por: Masuno, Makoto N., et al.
Publicado: (2004)

Cannot write session to /tmp/vufind_sessions/sess_5b4b4vm68igtl4ur4etpiuaccr