Crystal structure of adenovirus E3-19K bound to HLA-A2 reveals mechanism for immunomodulation

E3-19K binds to and retains MHC class I molecules in the endoplasmic reticulum, suppressing anti-Adenovirus (Ad) activities of T-cells. We determined the structure of the Ad serotype 2 (Ad2, species C) E3-19K–HLA-A2 complex to 1.95 Å resolution. Ad2 E3-19K binds to the N-terminus of the HLA-A2 groov...

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Detalles Bibliográficos
Autores principales: Li, Lenong, Muzahim, Yasameen, Bouvier, Marlene
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3492506/
https://www.ncbi.nlm.nih.gov/pubmed/23042604
http://dx.doi.org/10.1038/nsmb.2396

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3492506/
https://www.ncbi.nlm.nih.gov/pubmed/23042604
http://dx.doi.org/10.1038/nsmb.2396

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