Structure of a topoisomerase II-DNA-nucleotide complex reveals a new control mechanism for ATPase activity

Type IIA topoisomerases control DNA supercoiling and disentangle chromosomes by a complex, ATP-dependent strand passage mechanism. Although a general framework exists for type IIA topoisomerase function, the architecture of the full-length enzyme has remained undefined. Here we present the first str...

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Detalles Bibliográficos
Autores principales: Schmidt, Bryan H., Osheroff, Neil, Berger, James M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3492516/
https://www.ncbi.nlm.nih.gov/pubmed/23022727
http://dx.doi.org/10.1038/nsmb.2388

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3492516/
https://www.ncbi.nlm.nih.gov/pubmed/23022727
http://dx.doi.org/10.1038/nsmb.2388

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