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Structure of a topoisomerase II-DNA-nucleotide complex reveals a new control mechanism for ATPase activity
Type IIA topoisomerases control DNA supercoiling and disentangle chromosomes by a complex, ATP-dependent strand passage mechanism. Although a general framework exists for type IIA topoisomerase function, the architecture of the full-length enzyme has remained undefined. Here we present the first str...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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2012
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3492516/ https://www.ncbi.nlm.nih.gov/pubmed/23022727 http://dx.doi.org/10.1038/nsmb.2388 |