Cargando…

P-Glycoprotein Function at the Blood–Brain Barrier: Effects of Age and Gender

PURPOSE: P-glycoprotein (Pgp) is an efflux transporter involved in transport of several compounds across the blood–brain barrier (BBB). Loss of Pgp function with increasing age may be involved in the development of age-related disorders, but this may differ between males and females. Pgp function ca...

Descripción completa

Detalles Bibliográficos
Autores principales:	van Assema, Daniëlle M. E., Lubberink, Mark, Boellaard, Ronald, Schuit, Robert C., Windhorst, Albert D., Scheltens, Philip, Lammertsma, Adriaan A., van Berckel, Bart N. M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer-Verlag 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3492696/ https://www.ncbi.nlm.nih.gov/pubmed/22476967 http://dx.doi.org/10.1007/s11307-012-0556-0

Ejemplares similares

Reproducibility of quantitative (R)-[(11)C]verapamil studies
por: van Assema, Daniëlle ME, et al.
Publicado: (2012)

Blood–brain barrier P-glycoprotein function in healthy subjects and Alzheimer's disease patients: effect of polymorphisms in the ABCB1 gene
por: van Assema, Daniëlle ME, et al.
Publicado: (2012)

Evaluation of Tracer Kinetic Models for Analysis of [(18)F]FDDNP Studies
por: Yaqub, Maqsood, et al.
Publicado: (2009)

Test-retest variability of quantitative [(11)C]PIB studies in Alzheimer’s disease
por: Tolboom, Nelleke, et al.
Publicado: (2009)

Partial volume correction of brain PET studies using iterative deconvolution in combination with HYPR denoising
por: Golla, Sandeep S. V., et al.
Publicado: (2017)

Synthesis and Evaluation of New Fluorine-18 Labeled Verapamil Analogs To Investigate the Function of P-Glycoprotein in the Blood–Brain Barrier
por: Raaphorst, Renske M., et al.
Publicado: (2017)

Impact of New Scatter Correction Strategies on High-Resolution Research Tomograph Brain PET Studies
por: Mansor, Syahir, et al.
Publicado: (2016)

Model selection criteria for dynamic brain PET studies
por: Golla, Sandeep S. V., et al.
Publicado: (2017)

Quantification of [(18)F]florbetapir: A test–retest tracer kinetic modelling study
por: Golla, Sandeep SV, et al.
Publicado: (2018)

A novel partial volume correction method for accurate quantification of [(18)F] flortaucipir in the hippocampus
por: Wolters, Emma E., et al.
Publicado: (2018)

Quantification of Tau Load Using [(18)F]AV1451 PET
por: Golla, Sandeep S. V., et al.
Publicado: (2017)

Parametric methods for [(18)F]flortaucipir PET
por: Golla, Sandeep SV, et al.
Publicado: (2018)

First in human evaluation of [(18)F]PK-209, a PET ligand for the ion channel binding site of NMDA receptors
por: van der Aart, Jasper, et al.
Publicado: (2018)

First Evaluation of [(11)C]R116301 as an In Vivo Tracer of NK1 Receptors in Man
por: Wolfensberger, Saskia P. A., et al.
Publicado: (2009)

Repeatability of parametric methods for [(18)F]florbetapir imaging in Alzheimer’s disease and healthy controls: A test–retest study
por: Verfaillie, Sander CJ, et al.
Publicado: (2020)

Non-invasive Standardised Uptake Value for Verification of the Use of Previously Validated Reference Region for [(18)F]Flortaucipir and [(18)F]Florbetapir Brain PET Studies
por: de Vries, Bart M., et al.
Publicado: (2021)

Semi-quantitative cerebral blood flow parameters derived from non-invasive [(15)O]H(2)O PET studies
por: Koopman, Thomas, et al.
Publicado: (2017)

Quantification of the novel N-methyl-d-aspartate receptor ligand [(11)C]GMOM in man
por: van der Doef, Thalia F, et al.
Publicado: (2015)

Image Derived Input Functions: Effects of Motion on Tracer Kinetic Analyses
por: Mourik, Jurgen E. M., et al.
Publicado: (2010)

Quantification of P-glycoprotein function at the human blood-brain barrier using [(18)F]MC225 and PET
por: Mossel, Pascalle, et al.
Publicado: (2023)

Evaluation of P-glycoprotein function at the blood–brain barrier using [(18)F]MC225-PET
por: Mossel, Pascalle, et al.
Publicado: (2021)

Quantification of [(18)F]DPA-714 binding in the human brain: initial studies in healthy controls and Alzheimer's disease patients
por: Golla, Sandeep S V, et al.
Publicado: (2015)

Optimization of supervised cluster analysis for extracting reference tissue input curves in (R)-[(11)C]PK11195 brain PET studies
por: Yaqub, Maqsood, et al.
Publicado: (2012)

Off-line motion correction methods for multi-frame PET data
por: Mourik, Jurgen E. M., et al.
Publicado: (2009)

Tau pathology and relative cerebral blood flow are independently associated with cognition in Alzheimer’s disease
por: Visser, Denise, et al.
Publicado: (2020)

(R)-[(11)C]Verapamil PET studies to assess changes in P-glycoprotein expression and functionality in rat blood-brain barrier after exposure to kainate-induced status epilepticus
por: Syvänen, Stina, et al.
Publicado: (2011)

Cerebral blood flow, amyloid burden, and cognition in cognitively normal individuals
por: Ebenau, Jarith L., et al.
Publicado: (2022)

Discordant amyloid-β PET and CSF biomarkers and its clinical consequences
por: de Wilde, Arno, et al.
Publicado: (2019)

Differential associations between neocortical tau pathology and blood flow with cognitive deficits in early-onset vs late-onset Alzheimer’s disease
por: Visser, Denise, et al.
Publicado: (2022)

Why Is Amyloid-β PET Requested After Performing CSF Biomarkers?
por: Reimand, Juhan, et al.
Publicado: (2020)

Comparison of oxygen-15 PET and transcranial Doppler CO(2)-reactivity measurements in identifying haemodynamic compromise in patients with symptomatic occlusion of the internal carotid artery
por: Persoon, Suzanne, et al.
Publicado: (2012)

Precision estimates of relative and absolute cerebral blood flow in Alzheimer’s disease and cognitively normal individuals
por: Heeman, Fiona, et al.
Publicado: (2022)

PET and CSF amyloid-β status are differently predicted by patient features: information from discordant cases
por: Reimand, Juhan, et al.
Publicado: (2019)

Comparison of In Vitro Assays in Selecting Radiotracers for In Vivo P-Glycoprotein PET Imaging
por: Raaphorst, Renske M., et al.
Publicado: (2017)

Quantification of O-(2-[(18)F]fluoroethyl)-L-tyrosine kinetics in glioma
por: Koopman, Thomas, et al.
Publicado: (2018)

Hypometabolism of the posterior cingulate cortex is not restricted to Alzheimer's disease
por: Scheltens, Nienke M.E., et al.
Publicado: (2018)

Assessing Amyloid Pathology in Cognitively Normal Subjects Using (18)F-Flutemetamol PET: Comparing Visual Reads and Quantitative Methods
por: Collij, Lyduine E., et al.
Publicado: (2019)

Increased cerebral (R)-[(11)C]PK11195 uptake and glutamate release in a rat model of traumatic brain injury: a longitudinal pilot study
por: Folkersma, Hedy, et al.
Publicado: (2011)

An exploratory clinical study of p38α kinase inhibition in Alzheimer's disease
por: Scheltens, Philip, et al.
Publicado: (2018)

Quantification of [(11)C]-meta-hydroxyephedrine uptake in human myocardium
por: Harms, Hendrik J, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_d1442qlnrhhhmdqtoc3fj8n2ns