RRM2B Suppresses Activation of the Oxidative Stress Pathway and is Up-regulated by P53 During Senescence

RRM2B is the DNA damage-inducible small subunit of ribonucleotide reductase, the rate-limiting enzyme in de novo deoxyribonucleoside triphosphate synthesis. Although RRM2B is implicated in DNA repair and the maintenance of mitochondrial DNA content, the regulation and function of RRM2B in senescence...

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Detalles Bibliográficos
Autores principales: Kuo, Mei-Ling, Sy, Alexander J., Xue, Lijun, Chi, Martin, -C. Lee, Michelle T., Yen, Terence, Chiang, Mei-Iok, Chang, Lufen, Chu, Peiguo, Yen, Yun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3492868/
https://www.ncbi.nlm.nih.gov/pubmed/23139867
http://dx.doi.org/10.1038/srep00822

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3492868/
https://www.ncbi.nlm.nih.gov/pubmed/23139867
http://dx.doi.org/10.1038/srep00822

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