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Permeability of ergot alkaloids across the blood-brain barrier in vitro and influence on the barrier integrity

SCOPE: Ergot alkaloids are secondary metabolites of Claviceps spp. and they have been in the focus of research for many years. Experiments focusing on ergotamine as a former migraine drug referring to the ability to reach the brain revealed controversial results. The question to which extent ergot a...

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Detalles Bibliográficos
Autores principales: Mulac, Dennis, Hüwel, Sabine, Galla, Hans-Joachim, Humpf, Hans-Ulrich
Formato: Online Artículo Texto
Lenguaje:English
Publicado: WILEY-VCH Verlag 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3492916/
https://www.ncbi.nlm.nih.gov/pubmed/22147614
http://dx.doi.org/10.1002/mnfr.201100431