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The amyloid-β isoform pattern in cerebrospinal fluid in familial PSEN1 M139T- and L286P-associated Alzheimer's disease

There are several familial forms of Alzheimer's disease (AD) most of which are caused by mutations in the genes that encode the presenilin enzymes involved in the production of amyloid-β (Aβ) from the amyloid precursor protein (APP). In AD, Aβ forms fibrils that are deposited in the brain as pl...

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Detalles Bibliográficos
Autores principales: PORTELIUS, ERIK, FORTEA, JUAN, MOLINUEVO, JOSE LUIS, GUSTAVSSON, MIKAEL K., ANDREASSON, ULF, SANCHEZ-VALLE, RAQUEL
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3493058/
https://www.ncbi.nlm.nih.gov/pubmed/22307680
http://dx.doi.org/10.3892/mmr.2012.774