Computational analysis of novel drugs designed for use as acetylcholinesterase inhibitors and histamine H(3) receptor antagonists for Alzheimer's disease by docking, scoring and de novo evolution

Alzheimer's disease (AD) was first described by Alois Alzheimer in 1907. AD is the most prevalent dementia- related disease, affecting over 20 million individuals worldwide. Currently, however, only a handful of drugs are available and they are at best only able to offer some relief of symptoms...

Descripción completa

Detalles Bibliográficos
Autores principales: CHEN, PO-YUAN, TSAI, CHING-TSAN, OU, CHE-YEN, HSU, WEI-TSE, JHUO, MIEN-DE, WU, CHIEH-HSI, SHIH, TZU-CHING, CHENG, TZU-HURNG, CHUNG, JING-GUNG
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3493073/
https://www.ncbi.nlm.nih.gov/pubmed/22267207
http://dx.doi.org/10.3892/mmr.2012.757

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3493073/
https://www.ncbi.nlm.nih.gov/pubmed/22267207
http://dx.doi.org/10.3892/mmr.2012.757

Ejemplares similares