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siRNA knockdown of GPR18 receptors in BV-2 microglia attenuates N-arachidonoyl glycine-induced cell migration

BACKGROUND: Neurons are known to employ the endogenous cannabinoid system to communicate with other cells of the CNS. Endocannabioid signaling recruits microglia toward neurons by engaging cannabinoid CB(2) and abnormal cannabidiol (Abn-CBD) receptors. The Abn-CBD receptor is a prominent atypical ca...

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Detalles Bibliográficos
Autores principales: McHugh, Douglas, Wager-Miller, James, Page, Jeremy, Bradshaw, Heather B
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3493281/
https://www.ncbi.nlm.nih.gov/pubmed/22834922
http://dx.doi.org/10.1186/1750-2187-7-10