Loss of Prohibitin Membrane Scaffolds Impairs Mitochondrial Architecture and Leads to Tau Hyperphosphorylation and Neurodegeneration

Fusion and fission of mitochondria maintain the functional integrity of mitochondria and protect against neurodegeneration, but how mitochondrial dysfunctions trigger neuronal loss remains ill-defined. Prohibitins form large ring complexes in the inner membrane that are composed of PHB1 and PHB2 sub...

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Detalles Bibliográficos
Autores principales: Merkwirth, Carsten, Martinelli, Paola, Korwitz, Anne, Morbin, Michela, Brönneke, Hella S., Jordan, Sabine D., Rugarli, Elena I., Langer, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3493444/
https://www.ncbi.nlm.nih.gov/pubmed/23144624
http://dx.doi.org/10.1371/journal.pgen.1003021

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3493444/
https://www.ncbi.nlm.nih.gov/pubmed/23144624
http://dx.doi.org/10.1371/journal.pgen.1003021

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