A Targeted Glycan-Related Gene Screen Reveals Heparan Sulfate Proteoglycan Sulfation Regulates WNT and BMP Trans-Synaptic Signaling

A Drosophila transgenic RNAi screen targeting the glycan genome, including all N/O/GAG-glycan biosynthesis/modification enzymes and glycan-binding lectins, was conducted to discover novel glycan functions in synaptogenesis. As proof-of-product, we characterized functionally paired heparan sulfate (H...

Descripción completa

Detalles Bibliográficos
Autores principales: Dani, Neil, Nahm, Minyeop, Lee, Seungbok, Broadie, Kendal
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3493450/
https://www.ncbi.nlm.nih.gov/pubmed/23144627
http://dx.doi.org/10.1371/journal.pgen.1003031

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3493450/
https://www.ncbi.nlm.nih.gov/pubmed/23144627
http://dx.doi.org/10.1371/journal.pgen.1003031

Ejemplares similares