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A Germline Polymorphism of DNA Polymerase Beta Induces Genomic Instability and Cellular Transformation
Several germline single nucleotide polymorphisms (SNPs) have been identified in the POLB gene, but little is known about their cellular and biochemical impact. DNA Polymerase β (Pol β), encoded by the POLB gene, is the main gap-filling polymerase involved in base excision repair (BER), a pathway tha...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Public Library of Science
2012
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3493456/ https://www.ncbi.nlm.nih.gov/pubmed/23144635 http://dx.doi.org/10.1371/journal.pgen.1003052 |