The Polymorphic Pseudokinase ROP5 Controls Virulence in Toxoplasma gondii by Regulating the Active Kinase ROP18

Secretory polymorphic serine/threonine kinases control pathogenesis of Toxoplasma gondii in the mouse. Genetic studies show that the pseudokinase ROP5 is essential for acute virulence, but do not reveal its mechanism of action. Here we demonstrate that ROP5 controls virulence by blocking IFN-γ media...

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Detalles Bibliográficos
Autores principales: Behnke, Michael S., Fentress, Sarah J., Mashayekhi, Mona, Li, Lucy X., Taylor, Gregory A., Sibley, L. David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3493473/
https://www.ncbi.nlm.nih.gov/pubmed/23144612
http://dx.doi.org/10.1371/journal.ppat.1002992

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3493473/
https://www.ncbi.nlm.nih.gov/pubmed/23144612
http://dx.doi.org/10.1371/journal.ppat.1002992

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