Structural and Functional Insights into the HIV-1 Maturation Inhibitor Binding Pocket

Processing of the Gag precursor protein by the viral protease during particle release triggers virion maturation, an essential step in the virus replication cycle. The first-in-class HIV-1 maturation inhibitor dimethylsuccinyl betulinic acid [PA-457 or bevirimat (BVM)] blocks HIV-1 maturation by inh...

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Detalles Bibliográficos
Autores principales: Waki, Kayoko, Durell, Stewart R., Soheilian, Ferri, Nagashima, Kunio, Butler, Scott L., Freed, Eric O.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3493477/
https://www.ncbi.nlm.nih.gov/pubmed/23144615
http://dx.doi.org/10.1371/journal.ppat.1002997

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3493477/
https://www.ncbi.nlm.nih.gov/pubmed/23144615
http://dx.doi.org/10.1371/journal.ppat.1002997

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