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Bromodomain Protein Brd4 Plays a Key Role in Merkel Cell Polyomavirus DNA Replication
Merkel cell polyomavirus (MCV or MCPyV) is the first human polyomavirus to be definitively linked to cancer. The mechanisms of MCV-induced oncogenesis and much of MCV biology are largely unexplored. In this study, we demonstrate that bromodomain protein 4 (Brd4) interacts with MCV large T antigen (L...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3493480/ https://www.ncbi.nlm.nih.gov/pubmed/23144621 http://dx.doi.org/10.1371/journal.ppat.1003021 |