Bromodomain Protein Brd4 Plays a Key Role in Merkel Cell Polyomavirus DNA Replication

Merkel cell polyomavirus (MCV or MCPyV) is the first human polyomavirus to be definitively linked to cancer. The mechanisms of MCV-induced oncogenesis and much of MCV biology are largely unexplored. In this study, we demonstrate that bromodomain protein 4 (Brd4) interacts with MCV large T antigen (L...

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Detalles Bibliográficos
Autores principales: Wang, Xin, Li, Jing, Schowalter, Rachel M., Jiao, Jing, Buck, Christopher B., You, Jianxin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3493480/
https://www.ncbi.nlm.nih.gov/pubmed/23144621
http://dx.doi.org/10.1371/journal.ppat.1003021

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