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Variation in the Mechanical Unfolding Pathway of p53DBD Induced by Interaction with p53 N-Terminal Region or DNA
The tumor suppressor p53 plays a crucial role in the cell cycle checkpoints, DNA repair, and apoptosis. p53 consists of a natively unfolded N-terminal region (NTR), central DNA binding domain (DBD), C-terminal tetramerization domain, and regulatory region. In this paper, the interactions between the...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Public Library of Science
2012
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3493487/ https://www.ncbi.nlm.nih.gov/pubmed/23145047 http://dx.doi.org/10.1371/journal.pone.0049003 |