Mechanism of Selective VEGF-A Binding by Neuropilin-1 Reveals a Basis for Specific Ligand Inhibition

Neuropilin (Nrp) receptors function as essential cell surface receptors for the Vascular Endothelial Growth Factor (VEGF) family of proangiogenic cytokines and the semaphorin 3 (Sema3) family of axon guidance molecules. There are two Nrp homologues, Nrp1 and Nrp2, which bind to both overlapping and...

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Detalles Bibliográficos
Autores principales: Parker, Matthew W., Xu, Ping, Guo, Hou-Fu, Vander Kooi, Craig W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3493496/
https://www.ncbi.nlm.nih.gov/pubmed/23145112
http://dx.doi.org/10.1371/journal.pone.0049177

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3493496/
https://www.ncbi.nlm.nih.gov/pubmed/23145112
http://dx.doi.org/10.1371/journal.pone.0049177

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