Structures of SHV-1 β-Lactamase with Penem and Penam Sulfone Inhibitors That Form Cyclic Intermediates Stabilized by Carbonyl Conjugation

Bacterial β-lactamase enzymes are in large part responsible for the decreased ability of β-lactam antibiotics to combat infections. The inability to overcome β-lactamase mediated resistance spurred the development of inhibitors with penems and penam sulfones being amongst the most potent and broad s...

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Detalles Bibliográficos
Autores principales: Ke, Wei, Pattanaik, Priyaranjan, Bethel, Christopher R., Sheri, Anjaneyulu, Buynak, John D., Bonomo, Robert A., van den Akker, Focco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3493512/
https://www.ncbi.nlm.nih.gov/pubmed/23145056
http://dx.doi.org/10.1371/journal.pone.0049035

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3493512/
https://www.ncbi.nlm.nih.gov/pubmed/23145056
http://dx.doi.org/10.1371/journal.pone.0049035

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