Cargando…

The PDZ Protein GIPC Regulates Trafficking of the LPA(1) Receptor from APPL Signaling Endosomes and Attenuates the Cell’s Response to LPA

Lysophosphatidic acid (LPA) mediates diverse cellular responses through the activation of at least six LPA receptors – LPA(1–6,) but the interacting proteins and signaling pathways that mediate the specificity of these receptors are largely unknown. We noticed that LPA(1) contains a PDZ binding moti...

Descripción completa

Detalles Bibliográficos
Autores principales:	Varsano, Tal, Taupin, Vanessa, Guo, Lixia, Baterina, Oscar Y., Farquhar, Marilyn G.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3493537/ https://www.ncbi.nlm.nih.gov/pubmed/23145131 http://dx.doi.org/10.1371/journal.pone.0049227

Ejemplares similares

LPA(1), LPA(2), LPA(4), and LPA(6) receptor expression during mouse brain development
por: Suckau, Olga, et al.
Publicado: (2019)

Phosphorylation and Internalization of Lysophosphatidic Acid Receptors LPA(1), LPA(2), and LPA(3)
por: Alcántara-Hernández, Rocío, et al.
Publicado: (2015)

Effects of the LPA(1) Receptor Deficiency and Stress on the Hippocampal LPA Species in Mice
por: Tabbai, Sara, et al.
Publicado: (2019)

Regulation of T Cell Motility In Vitro and In Vivo by LPA and LPA2
por: Knowlden, Sara A., et al.
Publicado: (2014)

LPA receptor 1 mediates LPA-induced ovarian cancer metastasis: an in vitro and in vivo study
por: Yu, Xuechen, et al.
Publicado: (2016)

Phosphatidic Acid Stimulates Myoblast Proliferation through Interaction with LPA1 and LPA2 Receptors
por: Gomez-Larrauri, Ana, et al.
Publicado: (2021)

Stress, Depression, Resilience and Ageing: A Role for the LPA-LPA(1) Pathway
por: Dario, Moreno-Fernández Román, et al.
Publicado: (2018)

An LPA species (18:1 LPA) plays key roles in the self-amplification of spinal LPA production in the peripheral neuropathic pain model
por: Ma, Lin, et al.
Publicado: (2013)

ARH directs megalin to the endocytic recycling compartment to regulate its proteolysis and gene expression
por: Shah, Mehul, et al.
Publicado: (2013)

Lysophosphatidic acid and its receptors LPA(1) and LPA(3) mediate paclitaxel-induced neuropathic pain in mice
por: Uchida, Hitoshi, et al.
Publicado: (2014)

Visualization of the binding between gintonin, a Panax ginseng-derived LPA receptor ligand, and the LPA receptor subtypes and transactivation of the EGF receptor
por: Choi, Sun-Hye, et al.
Publicado: (2022)

LPA Is a Chemorepellent for B16 Melanoma Cells: Action through the cAMP-Elevating LPA(5) Receptor
por: Jongsma, Maikel, et al.
Publicado: (2011)

Lysophosphatidic Acid Induces Apoptosis of PC12 Cells Through LPA1 Receptor/LPA2 Receptor/MAPK Signaling Pathway
por: Zhang, Jie, et al.
Publicado: (2020)

LPA-induced suppression of periostin in human osteosarcoma cells is mediated by the LPA(1)/Egr-1 axis
por: Windischhofer, Werner, et al.
Publicado: (2012)

The LPA(3) Receptor: Regulation and Activation of Signaling Pathways
por: Solís, Karina Helivier, et al.
Publicado: (2021)

LPA Scheme for the LHC Luminosity Upgrade
por: Bhat, C
Publicado: (2009)

Lysophosphatidic acid receptors LPA(4) and LPA(6) differentially promote lymphocyte transmigration across high endothelial venules in lymph nodes
por: Hata, Erina, et al.
Publicado: (2016)

Lysophosphatidic Acid Induced Apoptosis, DNA Damage, and Oxidative Stress in Spinal Cord Neurons by Upregulating LPA4/LPA6 Receptors
por: Yang, Yifan, et al.
Publicado: (2022)

The autotaxin-LPA axis promotes membrane trafficking and secretion in yolk sac visceral endoderm cells
por: Koike, Seiichi, et al.
Publicado: (2023)

Lysophosphatidic acid LPA(1) and LPA(3) receptors play roles in the maintenance of late tissue plasminogen activator-induced central poststroke pain in mice
por: Ueda, Hiroshi, et al.
Publicado: (2018)

Mutant lpa1 Analysis of ZmLPA1 Gene Regulates Maize Leaf-Angle Development through the Auxin Pathway
por: Ji, Xiangzhuo, et al.
Publicado: (2022)

Cis-epistasis at the LPA locus and risk of cardiovascular diseases
por: Zeng, Lingyao, et al.
Publicado: (2021)

Lipid phosphate phosphatase inhibitors locally amplify lysophosphatidic acid LPA(1) receptor signalling in rat brain cryosections without affecting global LPA degradation
por: Aaltonen, Niina, et al.
Publicado: (2012)

Lateral access mechanism of LPA receptor probed by molecular dynamics simulation
por: Suenaga, Rieko, et al.
Publicado: (2022)

TNF-α and LPA promote synergistic expression of COX-2 in human colonic myofibroblasts: role of LPA-mediated transactivation of upregulated EGFR
por: Yoo, James, et al.
Publicado: (2013)

Identification of etiological agents by LPA and PCR in childhood meningitis
por: Khan, Mashal, et al.
Publicado: (2013)

lpa1-5525: A New lpa1 Mutant Isolated in a Mutagenized Population by a Novel Non-Disrupting Screening Method
por: Borlini, Giulia, et al.
Publicado: (2019)

The effect of LPA Thr3888Pro on lipoprotein(a) and coronary artery disease is modified by the LPA KIV-2 variant 4925G>A
por: Grüneis, Rebecca, et al.
Publicado: (2022)

Berberine Modulates LPA Function to Inhibit the Proliferation and Inflammation of FLS-RA via p38/ERK MAPK Pathway Mediated by LPA(1)
por: Wang, Hui, et al.
Publicado: (2019)

CB(1) and LPA(1) Receptors Relationship in the Mouse Central Nervous System
por: González de San Román, Estíbaliz, et al.
Publicado: (2019)

Modulation of lysophosphatidic acid (LPA) receptor activity: the key to successful neural regeneration?
por: Gross, Isabel, et al.
Publicado: (2019)

Gintonin influences the morphology and motility of adult brain neurons via LPA receptors
por: Kim, Do-Geun, et al.
Publicado: (2021)

Loss of FOXF1 expression promotes human lung-resident mesenchymal stromal cell migration via ATX/LPA/LPA1 signaling axis
por: Cao, Pengxiu, et al.
Publicado: (2020)

Lysophosphatidic acid, LPA: a bad boy becomes good
por: Budnik, Lygia T
Publicado: (2003)

Lysophosphatidic Acid (LPA) Signaling in Human and Ruminant Reproductive Tract
por: Wocławek-Potocka, Izabela, et al.
Publicado: (2014)

LPA Promotes T Cell Recruitment through Synthesis of CXCL13
por: Hui, Weili, et al.
Publicado: (2015)

Yap is required for ependymal integrity and is suppressed in LPA-induced hydrocephalus
por: Park, Raehee, et al.
Publicado: (2016)

maLPA1-null mice as an endophenotype of anxious depression
por: Moreno-Fernández, R D, et al.
Publicado: (2017)

The Role of Autotaxin and LPA Signaling in Embryonic Development, Pathophysiology and Cancer
por: Magkrioti, Christiana, et al.
Publicado: (2023)

Compensatory Upregulation of LPA(2) and Activation of the PI3K-Akt Pathway Prevent LPA(5)-Dependent Loss of Intestinal Epithelial Cells in Intestinal Organoids
por: Liang, Zhongxing, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_qrmgdpp8klfjp55subd6kqigp1