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Trigeminal Ganglion Neurons of Mice Show Intracellular Chloride Accumulation and Chloride-Dependent Amplification of Capsaicin-Induced Responses

Intracellular Cl(−) concentrations ([Cl(−)](i)) of sensory neurons regulate signal transmission and signal amplification. In dorsal root ganglion (DRG) and olfactory sensory neurons (OSNs), Cl(−) is accumulated by the Na(+)-K(+)-2Cl(−) cotransporter 1 (NKCC1), resulting in a [Cl(−)](i) above electro...

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Detalles Bibliográficos
Autores principales: Schöbel, Nicole, Radtke, Debbie, Lübbert, Matthias, Gisselmann, Günter, Lehmann, Ramona, Cichy, Annika, Schreiner, Benjamin S. P., Altmüller, Janine, Spector, Alan C., Spehr, Jennifer, Hatt, Hanns, Wetzel, Christian H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3493563/
https://www.ncbi.nlm.nih.gov/pubmed/23144843
http://dx.doi.org/10.1371/journal.pone.0048005