Spermine Attenuates the Action of the DNA Intercalator, Actinomycin D, on DNA Binding and the Inhibition of Transcription and DNA Replication

The anticancer activity of DNA intercalators is related to their ability to intercalate into the DNA duplex with high affinity, thereby interfering with DNA replication and transcription. Polyamines (spermine in particular) are almost exclusively bound to nucleic acids and are involved in many cellu...

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Detalles Bibliográficos
Autores principales: Wang, Sheng-Yu, Lee, Yueh-Luen, Lai, Yi-Hua, Chen, Jeremy J. W., Wu, Wen-Lin, Yuann, Jeu-Ming P., Su, Wang-Lin, Chuang, Show-Mei, Hou, Ming-Hon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3493566/
https://www.ncbi.nlm.nih.gov/pubmed/23144800
http://dx.doi.org/10.1371/journal.pone.0047101

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3493566/
https://www.ncbi.nlm.nih.gov/pubmed/23144800
http://dx.doi.org/10.1371/journal.pone.0047101

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