An Integrated Computational Approach to Rationalize the Activity of Non-Zinc-Binding MMP-2 Inhibitors

Matrix metalloproteinases are a family of Zn-proteases involved in tissue remodeling and in many pathological conditions. Among them MMP-2 is one of the most relevant target in anticancer therapy. Commonly, MMP inhibitors contain a functional group able to bind the zinc ion and responsible for undes...

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Detalles Bibliográficos
Autores principales: Di Pizio, Antonella, Agamennone, Mariangela, Aschi, Massimiliano
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3493580/
https://www.ncbi.nlm.nih.gov/pubmed/23144829
http://dx.doi.org/10.1371/journal.pone.0047774

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3493580/
https://www.ncbi.nlm.nih.gov/pubmed/23144829
http://dx.doi.org/10.1371/journal.pone.0047774

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