Prion protein facilitates uptake of zinc into neuronal cells

Zinc is released into the synaptic cleft upon exocytotic stimuli, although the mechanism for its reuptake into neurons is unresolved. Here we show that the cellular prion protein enhances the uptake of zinc into neuronal cells. This prion-protein-mediated zinc influx requires the octapeptide repeats...

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Detalles Bibliográficos
Autores principales: Watt, Nicole T., Taylor, David R., Kerrigan, Talitha L., Griffiths, Heledd H., Rushworth, Jo V., Whitehouse, Isobel J., Hooper, Nigel M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Pub. Group 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3493655/
https://www.ncbi.nlm.nih.gov/pubmed/23072804
http://dx.doi.org/10.1038/ncomms2135

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3493655/
https://www.ncbi.nlm.nih.gov/pubmed/23072804
http://dx.doi.org/10.1038/ncomms2135

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