BMK1 is involved in the regulation of p53 through disrupting the PML-MDM2 interaction

Promyelocytic leukemia protein (PML) modulates the p53 tumor suppressor through its interaction with p53 and MDM2. We found that activated BMK1 preferentially associates with PML isoform IV and disrupts PML-MDM2 interaction. Doxorubicin, a common chemotherapeutic agent, is known to promote PML-media...

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Detalles Bibliográficos
Autores principales: Yang, Q, Liao, L, Deng, X, Chen, R, Gray, N S., Yates, J R., Lee, JD
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3493705/
https://www.ncbi.nlm.nih.gov/pubmed/22869143
http://dx.doi.org/10.1038/onc.2012.332

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3493705/
https://www.ncbi.nlm.nih.gov/pubmed/22869143
http://dx.doi.org/10.1038/onc.2012.332

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