Paclitaxel and CYC3, an aurora kinase A inhibitor, synergise in pancreatic cancer cells but not bone marrow precursor cells

BACKGROUND: Amplification of aurora kinase A (AK-A) overrides the mitotic spindle assembly checkpoint, inducing resistance to taxanes. RNA interference targeting AK-A in human pancreatic cancer cell lines enhanced taxane chemosensitivity. In this study, a novel AK-A inhibitor, CYC3, was investigated...

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Detalles Bibliográficos
Autores principales: Lin, Y, Richards, F M, Krippendorff, B-F, Bramhall, J L, Harrington, J A, Bapiro, T E, Robertson, A, Zheleva, D, Jodrell, D I
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2012
Materias:
Translational Therapeutics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3493865/
https://www.ncbi.nlm.nih.gov/pubmed/23037716
http://dx.doi.org/10.1038/bjc.2012.450

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3493865/
https://www.ncbi.nlm.nih.gov/pubmed/23037716
http://dx.doi.org/10.1038/bjc.2012.450

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