Patterns of genomic loss of heterozygosity predict homologous recombination repair defects in epithelial ovarian cancer

BACKGROUND: Defects in BRCA1, BRCA2, and other members of the homologous recombination pathway have potential therapeutic relevance when used to support agents that introduce or exploit double-stranded DNA breaks. This study examines the association between homologous recombination defects and genom...

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Detalles Bibliográficos
Autores principales: Abkevich, V, Timms, K M, Hennessy, B T, Potter, J, Carey, M S, Meyer, L A, Smith-McCune, K, Broaddus, R, Lu, K H, Chen, J, Tran, T V, Williams, D, Iliev, D, Jammulapati, S, FitzGerald, L M, Krivak, T, DeLoia, J A, Gutin, A, Mills, G B, Lanchbury, J S
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2012
Materias:
Genetics & Genomics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3493866/
https://www.ncbi.nlm.nih.gov/pubmed/23047548
http://dx.doi.org/10.1038/bjc.2012.451

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3493866/
https://www.ncbi.nlm.nih.gov/pubmed/23047548
http://dx.doi.org/10.1038/bjc.2012.451

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