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Membrane immersion allows rhomboid proteases to achieve specificity by reading transmembrane segment dynamics
Rhomboid proteases reside within cellular membranes, but the advantage of this unusual environment is unclear. We discovered membrane immersion allows substrates to be identified in a fundamentally-different way, based initially upon exposing ‘masked’ conformational dynamics of transmembrane segment...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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eLife Sciences Publications, Ltd
2012
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3494066/ https://www.ncbi.nlm.nih.gov/pubmed/23150798 http://dx.doi.org/10.7554/eLife.00173 |