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p53 suppresses type II endometrial carcinomas in mice and governs endometrial tumour aggressiveness in humans
Type II endometrial carcinomas are a highly aggressive group of tumour subtypes that are frequently associated with inactivation of the TP53 tumour suppressor gene. We show that mice with endometrium-specific deletion of Trp53 initially exhibited histological changes that are identical to known prec...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
WILEY-VCH Verlag
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3494078/ https://www.ncbi.nlm.nih.gov/pubmed/22678923 http://dx.doi.org/10.1002/emmm.201101063 |