Identification of novel CDK9 and Cyclin T1-associated protein complexes (CCAPs) whose siRNA depletion enhances HIV-1 Tat function

BACKGROUND: HIV-1 Tat activates RNA Polymerase II (RNAP II) elongation of the integrated provirus by recruiting a protein kinase known as P-TEFb to TAR RNA at the 5(′) end of nascent viral transcripts. The catalytic core of P-TEFb contains CDK9 and Cyclin T1 (CCNT1). A human endogenous complexome ha...

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Detalles Bibliográficos
Autores principales: Ramakrishnan, Rajesh, Liu, Hongbing, Donahue, Hart, Malovannaya, Anna, Qin, Jun, Rice, Andrew P
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3494656/
https://www.ncbi.nlm.nih.gov/pubmed/23110726
http://dx.doi.org/10.1186/1742-4690-9-90

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3494656/
https://www.ncbi.nlm.nih.gov/pubmed/23110726
http://dx.doi.org/10.1186/1742-4690-9-90

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