ScFv Anti-Heparan Sulfate Antibodies Unexpectedly Activate Endothelial and Cancer Cells through p38 MAPK: Implications for Antibody-Based Targeting of Heparan Sulfate Proteoglycans in Cancer

Tumor development requires angiogenesis and anti-angiogenic therapies have been introduced in the treatment of cancer. In this context, heparan sulfate proteoglycans (HSPGs) emerge as interesting targets, owing to their function as co-receptors of major, pro-angiogenic factors. Accordingly, previous...

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Detalles Bibliográficos
Autores principales: Christianson, Helena C., van Kuppevelt, Toin H., Belting, Mattias
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3494658/
https://www.ncbi.nlm.nih.gov/pubmed/23152853
http://dx.doi.org/10.1371/journal.pone.0049092

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3494658/
https://www.ncbi.nlm.nih.gov/pubmed/23152853
http://dx.doi.org/10.1371/journal.pone.0049092

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