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Senataxin Associates with Replication Forks to Protect Fork Integrity across RNA-Polymerase-II-Transcribed Genes

Transcription hinders replication fork progression and stability. The ATR checkpoint and specialized DNA helicases assist DNA synthesis across transcription units to protect genome integrity. Combining genomic and genetic approaches together with the analysis of replication intermediates, we searche...

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Detalles Bibliográficos
Autores principales: Alzu, Amaya, Bermejo, Rodrigo, Begnis, Martina, Lucca, Chiara, Piccini, Daniele, Carotenuto, Walter, Saponaro, Marco, Brambati, Alessandra, Cocito, Andrea, Foiani, Marco, Liberi, Giordano
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3494831/
https://www.ncbi.nlm.nih.gov/pubmed/23141540
http://dx.doi.org/10.1016/j.cell.2012.09.041