Crawling from soft to stiff matrix polarizes the cytoskeleton and phosphoregulates myosin-II heavy chain

On rigid surfaces, the cytoskeleton of migrating cells is polarized, but tissue matrix is normally soft. We show that nonmuscle MIIB (myosin-IIB) is unpolarized in cells on soft matrix in 2D and also within soft 3D collagen, with rearward polarization of MIIB emerging only as cells migrate from soft...

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Detalles Bibliográficos
Autores principales: Raab, Matthew, Swift, Joe, P. Dingal, P.C. Dave, Shah, Palak, Shin, Jae-Won, Discher, Dennis E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2012
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3494847/
https://www.ncbi.nlm.nih.gov/pubmed/23128239
http://dx.doi.org/10.1083/jcb.201205056

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3494847/
https://www.ncbi.nlm.nih.gov/pubmed/23128239
http://dx.doi.org/10.1083/jcb.201205056

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