Glucocerebrosidase Mutations alter the endoplasmic reticulum and lysosomes in Lewy body disease

Lewy body disease (LBD) development is enhanced by mutations in the GBA gene coding for glucocerebrosidase (GCase). The mechanism of this association is thought to involve an abnormal lysosomal system and we therefore sought to evaluate if lysosomal changes contribute to the pathogenesis of idiopath...

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Detalles Bibliográficos
Autores principales: Kurzawa-Akanbi, Marzena, Hanson, Peter S, Blain, Peter G, Lett, Debra J, McKeith, Ian G, Chinnery, Patrick F, Morris, Christopher M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 2012
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3494984/
https://www.ncbi.nlm.nih.gov/pubmed/22803570
http://dx.doi.org/10.1111/j.1471-4159.2012.07879.x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3494984/
https://www.ncbi.nlm.nih.gov/pubmed/22803570
http://dx.doi.org/10.1111/j.1471-4159.2012.07879.x

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