Reverse translation of phase I biomarker findings links the activity of angiotensin-(1–7) to repression of hypoxia inducible factor-1α in vascular sarcomas

BACKGROUND: In a phase I study of angiotensin-(1–7) [Ang-(1–7)], clinical benefit was associated with reduction in plasma placental growth factor (PlGF) concentrations. The current study examines Ang-(1–7) induced changes in biomarkers according to cancer type and investigates mechanisms of action e...

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Detalles Bibliográficos
Autores principales: Petty, W Jeffrey, Aklilu, Mebea, Varela, Victor A, Lovato, James, Savage, Paul D, Miller, Antonius A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3495013/
https://www.ncbi.nlm.nih.gov/pubmed/22963500
http://dx.doi.org/10.1186/1471-2407-12-404

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3495013/
https://www.ncbi.nlm.nih.gov/pubmed/22963500
http://dx.doi.org/10.1186/1471-2407-12-404

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