Cargando…

Reverse translation of phase I biomarker findings links the activity of angiotensin-(1–7) to repression of hypoxia inducible factor-1α in vascular sarcomas

BACKGROUND: In a phase I study of angiotensin-(1–7) [Ang-(1–7)], clinical benefit was associated with reduction in plasma placental growth factor (PlGF) concentrations. The current study examines Ang-(1–7) induced changes in biomarkers according to cancer type and investigates mechanisms of action e...

Descripción completa

Detalles Bibliográficos
Autores principales:	Petty, W Jeffrey, Aklilu, Mebea, Varela, Victor A, Lovato, James, Savage, Paul D, Miller, Antonius A
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3495013/ https://www.ncbi.nlm.nih.gov/pubmed/22963500 http://dx.doi.org/10.1186/1471-2407-12-404

Ejemplares similares

Phase II Trial of Angiotensin-(1-7) for the Treatment of Patients with Metastatic Sarcoma
por: Savage, Paul D., et al.
Publicado: (2016)

Paraneoplastic Leukocytosis and Thrombocytosis as Prognostic Biomarkers in Non-small Cell Lung Cancer
por: BODDU, Prajwal, et al.
Publicado: (2016)

Musashi mediates translational repression of the Drosophila hypoxia inducible factor
por: Bertolin, Agustina P., et al.
Publicado: (2016)

Reversal of Bone Marrow Mobilopathy and Enhanced Vascular Repair by Angiotensin-(1-7) in Diabetes
por: Vasam, Goutham, et al.
Publicado: (2017)

Reversal of Hypoxic Pulmonary Hypertension by Hypoxia-Inducible Overexpression of Angiotensin-(1-7) in Pulmonary Endothelial Cells
por: Liu, Man-Ling, et al.
Publicado: (2020)

The Histone Deacetylase Inhibitor, Vorinostat, Represses Hypoxia Inducible Factor 1 Alpha Expression through Translational Inhibition
por: Hutt, Darren M., et al.
Publicado: (2014)

Hfq links translation repression to stress-induced mutagenesis in E. coli
por: Chen, Jiandong, et al.
Publicado: (2017)

Reversible and Rapid Transfer-RNA Deactivation as a Mechanism of Translational Repression in Stress
por: Czech, Andreas, et al.
Publicado: (2013)

Targeting PI3K/Akt represses Hypoxia inducible factor-1α activation and sensitizes Rhabdomyosarcoma and Ewing’s sarcoma cells for apoptosis
por: Kilic-Eren, Mehtap, et al.
Publicado: (2013)

HIF-1–dependent repression of equilibrative nucleoside transporter (ENT) in hypoxia
por: Eltzschig, Holger K., et al.
Publicado: (2005)

Puf3p induces translational repression of genes linked to oxidative stress
por: Rowe, William, et al.
Publicado: (2014)

Attenuation of Angiotensin II–Induced Hypertension in BubR1 Low‐Expression Mice Via Repression of Angiotensin II Receptor 1 Overexpression
por: Aoyagi, Yukihiko, et al.
Publicado: (2019)

Transcriptional repression of human cad gene by hypoxia inducible factor-1α
por: Chen, Ko-Fan, et al.
Publicado: (2005)

Transcriptional repression of hypoxia-inducible factor-1 (HIF-1) by the protein arginine methyltransferase PRMT1
por: Lafleur, Véronique N., et al.
Publicado: (2014)

Translational Repression in Malaria Sporozoites
por: Turque, Oliver, et al.
Publicado: (2016)

Arginine methylation augments Sbp1 function in translation repression and decapping
por: Bhatter, Nupur, et al.
Publicado: (2019)

Hypoxia induces differential translation of enolase/MBP-1
por: Sedoris, Kara C, et al.
Publicado: (2010)

PUM1 represses CDKN1B translation and contributes to prostate cancer progression
por: Li, Xin, et al.
Publicado: (2021)

SNF1-Related Protein Kinase 1 Activity Represses the Canonical Translational Machinery
por: Son, Seungmin, et al.
Publicado: (2022)

NSun2 delays replicative senescence by repressing p27 (KIP1) translation and elevating CDK1 translation
por: Tang, Hao, et al.
Publicado: (2015)

Hypoxia and the hypoxia inducible factor 1α activate protein kinase A by repressing RII beta subunit transcription
por: Lucia, Kristin, et al.
Publicado: (2020)

Hypoxia inducible factor 1α in vascular smooth muscle cells promotes angiotensin II-induced vascular remodeling via activation of CCL7-mediated macrophage recruitment
por: Qi, Dan, et al.
Publicado: (2019)

Vascular Changes and Hypoxia in Periodontal Disease as a Link to Systemic Complications
por: Celik, Dilek, et al.
Publicado: (2021)

Data in support of alpha1beta1 and integrin-linked kinase interact and modulate angiotensin II effects in vascular smooth muscle cells
por: Moraes, João Alfredo, et al.
Publicado: (2015)

Different Effects of Angiotensin II and Angiotensin-(1-7) on Vascular Smooth Muscle Cell Proliferation and Migration
por: Zhang, Feng, et al.
Publicado: (2010)

Effects of Angiotensin-(1-7) and Angiotensin II on Acetylcholine-Induced Vascular Relaxation in Spontaneously Hypertensive Rats
por: Zhang, Feng, et al.
Publicado: (2019)

Insight into Hypoxia Tolerance in Cowpea Bruchid: Metabolic Repression and Heat Shock Protein Regulation via Hypoxia-Inducible Factor 1
por: Ahn, Ji-Eun, et al.
Publicado: (2013)

Xenopus CAF1 requires NOT1-mediated interaction with 4E-T to repress translation in vivo
por: Waghray, Shruti, et al.
Publicado: (2015)

Makorin 1 controls embryonic patterning by alleviating Bruno1-mediated repression of oskar translation
por: Dold, Annabelle, et al.
Publicado: (2020)

EWS/FLI1 Characterization, Activation, Repression, Target Genes and Therapeutic Opportunities in Ewing Sarcoma
por: Yasir, Muhammad, et al.
Publicado: (2023)

A randomized pilot phase I study of modified carcinoembryonic antigen (CEA) peptide (CAP1-6D)/montanide/GM-CSF-vaccine in patients with pancreatic adenocarcinoma
por: Geynisman, Daniel M, et al.
Publicado: (2013)

Sanguinarine Reverses Pulmonary Vascular Remolding of Hypoxia-Induced PH via Survivin/HIF1α-Attenuating Kv Channels
por: Fan, Fenling, et al.
Publicado: (2021)

Reversal of aging-associated increase in myelopoiesis and expression of alarmins by angiotensin-(1–7)
por: Chittimalli, Kishore, et al.
Publicado: (2023)

Hypoxia and Chromatin: A Focus on Transcriptional Repression Mechanisms
por: Batie, Michael, et al.
Publicado: (2018)

Role of hypoxia in Diffuse Large B-cell Lymphoma: Metabolic repression and selective translation of HK2 facilitates development of DLBCL
por: Bhalla, Kavita, et al.
Publicado: (2018)

POS-1 and GLD-1 repress glp-1 translation through a conserved binding-site cluster
por: Farley, Brian M., et al.
Publicado: (2012)

Pericyte, but not astrocyte, hypoxia inducible factor-1 (HIF-1) drives hypoxia-induced vascular permeability in vivo
por: Baumann, Julia, et al.
Publicado: (2022)

Angiotensin converting enzyme 1 in the median preoptic nucleus contributes to chronic intermittent hypoxia hypertension
por: Faulk, Katelynn E., et al.
Publicado: (2017)

Prolonged Pseudohypoxia Targets Ambra1 mRNA to P-Bodies for Translational Repression
por: Pourpirali, Somayeh, et al.
Publicado: (2015)

YB-1 regulates tiRNA-induced Stress Granule formation but not translational repression
por: Lyons, Shawn M., et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_h1v27ip8rdie5uuv41cp98v4uk