An ancient history of gene duplications, fusions and losses in the evolution of APOBEC3 mutators in mammals

BACKGROUND: The APOBEC3 (A3) genes play a key role in innate antiviral defense in mammals by introducing directed mutations in the DNA. The human genome encodes for seven A3 genes, with multiple splice alternatives. Different A3 proteins display different substrate specificity, but the very basic qu...

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Detalles Bibliográficos
Autores principales: Münk, Carsten, Willemsen, Anouk, Bravo, Ignacio G
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3495650/
https://www.ncbi.nlm.nih.gov/pubmed/22640020
http://dx.doi.org/10.1186/1471-2148-12-71

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3495650/
https://www.ncbi.nlm.nih.gov/pubmed/22640020
http://dx.doi.org/10.1186/1471-2148-12-71

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