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Computational codon optimization of synthetic gene for protein expression

BACKGROUND: The construction of customized nucleic acid sequences allows us to have greater flexibility in gene design for recombinant protein expression. Among the various parameters considered for such DNA sequence design, individual codon usage (ICU) has been implicated as one of the most crucial...

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Detalles Bibliográficos
Autores principales: Chung, Bevan Kai-Sheng, Lee, Dong-Yup
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3495653/
https://www.ncbi.nlm.nih.gov/pubmed/23083100
http://dx.doi.org/10.1186/1752-0509-6-134