Nitric oxide-induced eosinophil apoptosis is dependent on mitochondrial permeability transition (mPT), JNK and oxidative stress: apoptosis is preceded but not mediated by early mPT-dependent JNK activation

BACKGROUND: Eosinophils are critically involved in the pathogenesis of asthma. Nitric oxide (NO) is produced in high amounts in asthmatic lungs and has an important role as a regulator of lung inflammation. NO was previously shown to induce eosinophil apoptosis mediated via c-jun N-terminal kinase (...

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Detalles Bibliográficos
Autores principales: Ilmarinen-Salo, Pinja, Moilanen, Eeva, Kinnula, Vuokko L, Kankaanranta, Hannu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3495716/
https://www.ncbi.nlm.nih.gov/pubmed/22920281
http://dx.doi.org/10.1186/1465-9921-13-73

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3495716/
https://www.ncbi.nlm.nih.gov/pubmed/22920281
http://dx.doi.org/10.1186/1465-9921-13-73

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