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The Anti-Epileptic Drug Valproic Acid (VPA) Inhibits Steroidogenesis in Bovine Theca and Granulosa Cells In Vitro

Valproic acid (VPA) is used widely to treat epilepsy and bipolar disorder. Women undergoing VPA treatment reportedly have an increased incidence of polycystic ovarian syndrome (PCOS)-like symptoms including hyperandrogenism and oligo- or amenorrhoea. To investigate potential direct effects of VPA on...

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Detalles Bibliográficos
Autores principales: Glister, Claire, Satchell, Leanne, Michael, Anthony E., Bicknell, Andrew B., Knight, Philip G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3495868/
https://www.ncbi.nlm.nih.gov/pubmed/23152920
http://dx.doi.org/10.1371/journal.pone.0049553