On the Specificity of Heparin/Heparan Sulfate Binding to Proteins. Anion-Binding Sites on Antithrombin and Thrombin Are Fundamentally Different

BACKGROUND: The antithrombin–heparin/heparan sulfate (H/HS) and thrombin–H/HS interactions are recognized as prototypic specific and non-specific glycosaminoglycan (GAG)–protein interactions, respectively. The fundamental structural basis for the origin of specificity, or lack thereof, in these inte...

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Detalles Bibliográficos
Autores principales: Mosier, Philip D., Krishnasamy, Chandravel, Kellogg, Glen E., Desai, Umesh R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3495972/
https://www.ncbi.nlm.nih.gov/pubmed/23152789
http://dx.doi.org/10.1371/journal.pone.0048632

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3495972/
https://www.ncbi.nlm.nih.gov/pubmed/23152789
http://dx.doi.org/10.1371/journal.pone.0048632

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