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MIBE acts as antagonist ligand of both estrogen receptor α and GPER in breast cancer cells

INTRODUCTION: The multiple biological responses to estrogens are mainly mediated by the classical estrogen receptors ERα and ERβ, which act as ligand-activated transcription factors. ERα exerts a main role in the development of breast cancer; therefore, the ER antagonist tamoxifen has been widely us...

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Detalles Bibliográficos
Autores principales: Lappano, Rosamaria, Santolla, Maria Francesca, Pupo, Marco, Sinicropi, Maria Stefania, Caruso, Anna, Rosano, Camillo, Maggiolini, Marcello
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3496129/
https://www.ncbi.nlm.nih.gov/pubmed/22251451
http://dx.doi.org/10.1186/bcr3096