Phospho-ibuprofen (MDC-917) suppresses breast cancer growth: an effect controlled by the thioredoxin system

INTRODUCTION: We have recently synthesized phospho-ibuprofen (P-I; MDC-917), a safer derivative of ibuprofen, which has shown anti-cancer activity. We investigated its efficacy and mechanism of action in the treatment of breast cancer in preclinical models. METHODS: We evaluated the anti-breast-canc...

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Detalles Bibliográficos
Autores principales: Sun, Yu, Rowehl, Leahana M, Huang, Liqun, Mackenzie, Gerardo G, Vrankova, Kvetoslava, Komninou, Despina, Rigas, Basil
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3496138/
https://www.ncbi.nlm.nih.gov/pubmed/22293394
http://dx.doi.org/10.1186/bcr3105

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3496138/
https://www.ncbi.nlm.nih.gov/pubmed/22293394
http://dx.doi.org/10.1186/bcr3105

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